Humane Endpoints and Acute Toxicity Testing

Pain management and humane endpoints.

Humane endpoints in the efficacy testing of swine erysipelas vaccines.

For licensing the efficacy of vaccines for veterinary use has to be demonstrated by well-controlled laboratory experiments in which vaccinated and untreated animals of the target species are challenged. Erysipelas challenge tests cause extreme suffering of the unprotected animals with high fever, apathy, large skin lesions, and even death. This paper describes a standardised procedure for the v...

Humane endpoints for infectious disease animal models.

Since the work of pioneers such as Jenner and Pasteur (Fenner et al. 1997) more than a century ago, animal models have provided essential information in the study of infectious diseases. Although much experimentation can now be accomplished with in vitro systems, animals continue to be necessary for this field for studying the process of inflammation, specific infectious diseases, and pharmacol...

Studying humane endpoints in a rat model of mammary carcinogenesis

Objective(s): The present work intended to clearly define the most adequate humane endpoints in an experimental assay of mammary carcinogenesis in rats. Materials and Methods: Animals were observed twice a day; all parameters were registered once a week and the euthanasia endpoints were established in order to monitor the animal welfare/...

Refinement of vaccine potency testing with the use of humane endpoints.

Public concern over the use of laboratory animals has increased in recent years. Laboratory animal procedures involving unrelieved pain and distress (e.g., the footpad injection of rodents with Freund's adjuvant), which were routine in the past, now require strong justification. Moral concern is reflected in the existing legislation on animal experimentation in the United States (CFR 1992) and ...